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Many preclinical studies have indicated that Ea exhibits neuroprotective effects by anti-apoptosis and reduction of neuroinflammation, mediated by the p38 MAPK pathway, TLR4/NF-B pathway, and PI3K/Akt pathway [9599]

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[DOI] [PubMed] [Google Scholar] 157.Gottlieb P, Shen LG, Chimezie E, Bahng S, Kenney ME, Horowitz B, Ben-Hur E

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Modification of intracellular compounds The high energy doses carried by UV radiation lead to disorders of cellular redox balance, and in consequence, lead to oxidative modifications of lipids, nucleic acids, and proteins, which interfere with cellular metabolism by initiating photoreaction processes [22, 32]