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G.LengyelE.2010An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis, 103
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Currently, several pan-inhibitors, including ivaltinostat (CG200745), AR-42, abexinostat (PCI-24781), bisthianostat (CF-367), and sodium valproate, are under clinical trials for various tumors
318 Proteins that escape monitoring by the UPS can clump together, creating harmful substances that are difficult for the proteasome to break down and remove
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