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While the number of Americans using GLP-1 medications continues to be high, the side effects and the weight gain many report after stopping the drug have some questioning the drug's long-term effects

This study demonstrates that endothelial GR is critical to regulate the magnitude of the inflammatory process in response to LPS, and that glucocorticoid anti-inflammatory effects on the endothelium are mediated via GR repression of NF-B [81]

Weeks 9 to 12 (dose escalation to 1.2 mg) This is often the peak side effect period

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