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We used publicly available CRISPR sgRNA design tools that optimize on-target and minimize off-target genome editing ( and pooled human metabolic library (Birsoy et al., 2015) to identify 10 sgRNAs for each gene

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also found that the diversity of the gut microbiota was positively associated with the response to statin therapy (rosuvastatin 10 mg/d for 48 weeks) in hyperlipidemic patients

228,229 Genetic studies suggest that polymorphisms in the aldose reductase gene influence individual susceptibility to DPN, 230 highlighting the potential for personalized therapies

R., Volek, J
