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Ferroptosis has gained lot of attention, these past few years owing to its importance in a wide number of human pathologies including solid cancers and hematopoietic malignancies

This mechanistic switch leads to oxidative DNA damage and enhanced carcinogenesis, accounting for the population-specific toxicity (246)

The exercise protocol involved 5 weekly sessions of treadmill running at an intensity of 6070% of maximum speed (23 m/min), including 2-min rest intervals, for a total duration of 8 weeks

Nevertheless, these effects place LA at the cross-road of insulin- and JNK signaling favoring glucose uptake and metabolism, thus ameliorating insulin resistance and improving the status of diabetes.

Cell 71 , 411421 (1992)

FTH1, SLC7A11, GPX4 and STAT3 are upregulated in 5-FU-resistant cells