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4.3 Oxidative stress promotes the progression of diabetes toward diabetic cognitive dysfunction Cognitive impairment is one of the complications of diabetes, characterized by structural and pathological changes in the brain, and increasing research indicates that oxidative stress plays a pivotal role in cognitive impairment (42)

Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy

Glutathiones reduced form (GSH): Carries an extra electron (hydrogen) Donates hydrogen (electron) to inflammation-causing free radicals to neutralize their effect Glutathione peroxidase enzyme Requires selenium Converts two hydrogen peroxides into two water molecules Glutathiones oxidized form (GSSG): State of glutathione after losing its electron Forms a disulfide bridge between two glutathione molecules Glutathione reductase enzyme Glutathione can be recycled back to its reduced form using NADPH (reducing agent, electron donor)