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The potential causal effects of epilepsy on oxidative stress biomarkers were also evaluated, showing that epilepsy is potentially associated with increased UA and TBIL as well as decreased zinc

doi: 10.3390/biomedicines9081074

Canonical Smad2/3 signaling is a well-established mechanism of TGF--driven extracellular-matrix (ECM) synthesis

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The most studied mechanisms include: upregulation of growth hormone receptors in fibroblasts (increasing sensitivity to healing signals), activation of the FAK-paxillin pathway (promoting cell adhesion and migration), modulation of the nitric oxide system through Src-Caveolin-1-eNOS phosphorylation (enhancing vascular function), and dual activation of the Egr-1/NAB2 gene loop (promoting organized, non-chaotic blood vessel growth)

Additionally, they found that the GPX4 inhibitor RSL3 improves the anti-cancer effects of cisplatin by enhancing ferroptosis in vitro and in vivo (121, 122)