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Similar to GOG study participants receiving combination endocrine therapy, our patient mainly experienced low-grade toxicity, with chronic joint pain managed with analgesics and stable performance status ( More contemporary trials have explored the blockade of the PI3K/AKT/mTOR pathway as a method of overcoming resistance to endocrine therapy through synergistic antitumor effects

SP1-activated CFL2 promotes high glucose-induced retinal pigment epithelial cell injury and involves the AMPK/mTOR pathway

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