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21 Thus, therapeutic approaches for iron overload include direct or indirect modulation of hepcidin expression to reduce iron absorption

This makes them more susceptible to toxins, which can lead to liver congestion
doi: 10.1016/j.yrtph.2006.06.002

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Lapidot T

As such, it may be included in the list of genes worth screening in patients with ventricular noncompaction or other diseases involving dysregulation of ECM degradation