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In addition, MMP-mediated initiation of KLK-5 activation leads to further activation of LL-37, the processed form of cathelicidin

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doi: 10.1074/JBC.M000604200 103 MahutBDelclauxCTillie-LeblondIGossetPDelacourtCZerah-LancnerFet al

In a study of Parkinsons disease that used a 6-hydroxydopamine-Parkinsons disease mouse model, treatment of SH-SY5Y cells with SFN was found to have a protective effect on the neurons, which was attributed to the observed increases in active nuclear Nrf2 protein, Nrf2 mRNA, and total glutathione levels and inhibition of neuronal tissue apoptosis [24]