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The polyol pathway leads to the conversion of glucose to sorbitol and further to fructose, thus reducing the availability of cofactors such as NADPH needed for the glutathione peroxidaseglutathione reductase system, rendering the cell more vulnerable to reactive oxygen species (ROS), and therefore reinforcing oxidative stress [39][40]

Because exercise challenges many of the same systemsmitochondrial adenosine triphosphate (ATP) generation, redox homeostasis, calcium flux, and contractile efficiencythe biological overlap between taurine-dependent pathways and exercise-induced stress creates a logical basis for exploring how taurine might enhance the adaptive benefits of training in older adults

Oxidation and S-nitrosylation of cysteines in human cytosolic and mitochondrial glutaredoxins: Effects on structure and activity

Duan W, Li X, Shi J, Guo Y, Li Z, Li C