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Additionally, CBD leads to dysregulation of calcium homeostasis, mitochondrial Ca 2+ overload, stable mitochondrial transition pore formation, loss of mitochondrial membrane potential, and release of cytochrome c [151,155,156]

doi: 10.1016/j.febslet.2009.12.012

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Loss of axonal terminal plasticity may trigger distal nerve fiber degeneration and nociceptive hypersensitivity (Thomas et al., 2023)