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These results support a model in which EBNA2 and MYC coordinate a redox defense program, increasing one-carbon metabolism to support glutathione biosynthesis needed to suppress ferroptosis, while also providing carbon units for de novo purine synthesis (12) (Fig
It is reported that 5-ASA ameliorates UC in mice through dual mechanisms of preserving intestinal epithelial barrier integrity and modulating gut microbiota composition, with concomitant suprpression of JNK and p38 MAPK phosphorylation in colonic macrophages (Qu et al., 2017
This result was not affected by the inclusion of the ECA cohort
Sterile Water vs
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine
18 , e1010283 (2022)
