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Canavaninosuccinate inhibits the ornithine decarboxylate enzyme, hindering the biosynthesis of polyamines such as spermine, spermidine, and putrescine (D'mello, 2003a)

Issa GC, Kantarjian HM, Wang F, Gonzlez GN, Borthakur G , Tang G, Bueso-Ramos CE, Kanagal-Shamanna R, Hidalgo Lopez JE, Zhao C, Coyle M, Takahashi K, Jain P, Ravandi F, Kadia T, Garcia-Manero G, Jabbour EJ, Futreal A, Cortes JE

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Therefore, a phage therapy strategy that leverages such a trade-off could result in improved clinical outcomes by decreasing bacterial burden and by selecting for surviving bacterial mutants that are less resistant to antibiotics or less virulent 8

The parallel to BPC-157 is instructive: theoretical concerns deserve monitoring but should not override evidence of safety