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Methods 2017 14:4 14 , 331332 (2017)

Smaller rotaxanes may provide improved biodistribution and clearance profiles, potentially reducing off-target effects and allowing for more defined structures that enable better control over drug release and targeting 17

This increases the risk of developing age-related diseases

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Parkin facilitates the process of ubiquitination of proteins in the outer membrane of damaged mitochondria, which triggers mitophagy through the autophagy-lysosome pathway