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In agreement with their single-drug effects, both (M+D)/2 and (M+D+V)/3 downregulated proteins linked to mitochondrial ATP synthesis and cell cycle ( Supplementary Figures S5 , S6
The potential for gastrointestinal adverse effects, particularly nausea and vomiting, may lead to dehydration and worsening of renal function in vulnerable patients
The combination is significantly more effective than either modality alone
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