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Heightened systemic inflammatory states appear to worsen COVID-19 outcomes by initiating a counter-regulatory response, which includes the upregulation of levels of the ACE2 receptor and its associated peptidases 11

This powerful combination plays an essential role in maintaining a strong immune system, healthy vision, flexible joints, and optimal brain function

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Sci., 4: 561-566

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Howard J, Beckwith L, Espinosa M, Tyler R (1995) Development of infants born to cocaine-abusing women: biologic/maternal influences