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At a gross structural level, the most obvious differences between larger species, such as human and pig, and the rodent ENS is the presence of a single layer of submucosal ganglia in the rodent intestine versus two distinct layers in the human and pig (29)

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Additionally, multiple reports confirm that adipocytes secrete a range of paracrine factors relevant to MM dynamics, notably stem cell factor, adiponectin, leptin, and IL-2