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The reasons are multifaceted: rodent models of neurodegeneration imperfectly recapitulate human disease
Endocannabinoid pathways

Rudie et al., Autism-Associated Promoter Variant in MET Impacts Functional and Structural Brain Networks, Neuron, vol

Upon methylation, NAM becomes irretrievable for NAD + synthesis (Trammell and Brenner, 2015)

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7-3/ Table 7-2)