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The C9orf72 DPRs also interact with mitochondrial proteins, resulting in mitochondrial dysfunction, inflammation, and neurotoxicity (Gendron and Petrucelli, 2018)

These differences may reflect variation in linkage disequilibrium structure across populations, limited representation of American Latino ancestry in publicly available GWAS datasets, or differences in statistical power between studies

Mass spec confirmed the correct sequence without ambiguity

Under ER stress, however, basal RIDD is inefficient and therefore IRE1s XBP1s splicing activity is initiated, whereas RIDD gradually increases

Current Pharmaceutical Design , 17(18), 18031823

Chen et al., (87), showed in their work that alcohol consumption leads to hepatic acrolein accumulation and a decrease in glutathione-s-transferase-Pi (GSTP) that helps to metabolize acrolein