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Epilepsia 53 , 5157 (2012)

[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Tian Y., Lu J., Qiao Y

A recent research study in a 6-OHDA-induced PD model showed that intraperitoneal injection of different doses of silymarin (100, 200 or 300 mg/kg bw) for 15 days could increase the activity of antioxidant enzymes in the brain, reduce the level of lipid peroxidation, repair 6-OHDA-induced sports injury and dose-dependently increase the total number of surviving neurons in the dense part of the substantia nigra 207

This isoenzyme is also involved in the modulation of the apoptotic cascade through its interaction with cJNK

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