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FGF-21 levels are seen to be raised in patients who have muscle involvement, and thus, in cases with suspected mitochondrial myopathies, the noninvasive measurement of the growth factor acts as a helpful and sensitive first-line investigation in the diagnostic process [24, 25]

Moreover, PQQ can modulate inflammatory pathways by interacting with transcription factors such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), which promotes the transcription of proinflammatory interleukins [41]

Some CCAs (e.g

Hereditary angioedema (HAE) and the very rare acquired angioedema are the two syndromes that cause angioedema

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& Pappachen, J