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Although the symptoms reported in epidemiologic studies may be indicative of adverse effects, they were highly nonspecific and did not provide insight into the severity of effects or underlying mechanisms

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Animal models of psychosis generally posit a role for increased glutamate levels, particularly in medial temporal lobe regions, that leads to reduced hippocampal volume (Lieberman et al

DKO preadipocytes were then stably transduced with pBabe retrovirus containing the cDNA for the human IR (B isoform) or the L973F-IR
