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doi: 10.1016/j.jep.2008.08.001
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To a large extent, this tolerance development can be compensated for by gradually titrating the medication dose upwards, usually by adding a second dose in the early afternoon to provide reasonable all-day appetite control
The sealed crimped stopper maintains sterility and benzyl alcohol remains stable across this range
Also, certain components of medicinal herbs are known to be metabolized to reactive metabolites that have been associated with toxic reactions
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