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Like SOD1 G93A mice treated with Cu (II)-atsm, SOD1 G37R mice that received this copper supplementation show decreased levels of copper-deficient SOD1 in their spinal cords (Hilton et al., 2018

ALS pathology involves degeneration of upper and lower motor neurons, misfolded protein accumulation (e.g., TDP-43), mitochondrial dysfunction, oxidative stress, neuroinflammation, and excitotoxicity [100]

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A statistical test for GO-term enrichment using the genes with the 1000 most significant SNPs was conducted using AgriGO ( p -value 0.05
This approach not only overcomes the resistance associated with single therapies but also targets tumor cells through multiple mechanisms, thus enhancing overall treatment efficacy (134)
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