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Since the year 2000, multiple studies and subsequent systematic reviews have pointed to the potential therapeutic applications of carnitine for diseases impacting cognition including dementia and hepatic encephalopathy (Hudson and Tabet, 2003

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They also showed that CPT1A overexpression suppressed the nuclear factor erythroid-2-related factor 2/heme oxygenase-1 and nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome signaling pathways