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Other protozoan parasites also have the same Fe-SOD, such as and , where enzyme-mediated free radical catabolism is fully Fe-SOD dependent [30]

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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+

J Clin Endocrinol Metab (2000) 85(9):303642

Research indicates that concentrations of up to 2% in leave-on products (such as lotions and serums) are well-tolerated by most skin types, showing no significant adverse effects or irritation in long-term dermatological studies