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Introduction Depression is one of the leading mental disorders, and the number of people with depression has reached approximately 280 million worldwide from World Health Organization (WHO) statistics, making it a major contributor to the overall global burden of diseases (World Health Organization, 2023a,b)

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Another study showed that intra-articular injection of Botulinum Toxin A inhibited cartilage degradation in an OA model rat, and Lip-1 could further enhance this chondroprotective effect (Zeng et al., 2024)

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FDA completely fails to account for this additional body burden in women when comparing exposure to the RfC and MRL

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