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63 Together, these findings indicate that (i) the sensitivity of tumors to insulin and IGF-1 parallels their response to CR, and (ii) neither the activation status of PI3KAKT per se nor mutation status of individual genes predicts for the sensitivity of tumors to both growth factors and CR

GRD1 Background Gene Name: GSR UniProt Entry: P00390 NCBI Gene Entry: 2936 Application Information Molecular Weight: Predicted, 56 kDa

doi: 10.1007/s10048-011-0294-5, 87 MilaneseC.GabrielsS.BarnhoornS.CerriS.UlusoyA.GornatiS

1 x 10ml Bacteriostatic water is sterile non-pyrogenic water that contains benzyl alcohol which is added as a bacteriostatic preservative

Stimulation of ER induces transactivation of the epidermal growth factor receptor (EGFR), activating downstream Ras/RAF/MEK/ERK and Ras/PI3K/PTEN/Akt signaling pathways