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For instance, a case was reported of a 28-year-old man who suffered ventricular fibrillation after excessive ED intake and required hospitalization, although he was ultimately discharged in good health after 6 days [23]

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Both approaches work, and the most important factor is consistency rather than precise timing

Animal models confirm TMAOs pathogenic role: reducing plasma TMAO slows CKD progression (138), while TMAO accelerates diabetic nephropathy by activating NLRP3 inflammasome, promoting IL-1/IL-18 release, and worsening renal dysfunction/fibrosis (139)

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