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In vitro and in vivo experiments showed that curcumin inhibited the proliferation, migration, and metastasis of colorectal cancer cells by inhibiting heparanase expression
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Although the rat GCLC promoter also contain a distal ARE 4 kb upstream [117], the 1.8 kb 5-flanking region of the rat GCLC does not contain any consensus ARE element (5-G/ATG/TAG/CNNNGCA/G-3) [105] and yet TBH treatment can induce the reporter activity driven by this 1.8 kb construct [118]
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