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It is possible that the mitochondrial glutathione pool might also be affected considering the existence of glutathione carriers through the mitochondrial membrane 67,68 , thus explaining the improved mitochondrial activity we observed
Additionally, studies have indicated that Zhilong Huoxue Tongyu capsule reduces MIRI-induced ferroptosis by upregulating Nrf2 via the PI3K/AKT signaling pathway and triggering the activation of the HO-1/GPX4 pathway (Zhao et al., 2024)

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Takeda S, Sato N, Morishita R (2014) Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

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