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CDI augments primary BA synthesis in HFD-induced obese mice Although lack of bacteria-derived enzymes and the consequent decreased deconjugation could result in excess conjugated primary BAs in HFD-fed mice, the sustained nature of this increase suggested an added contribution from BA bio-synthetic machinery

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Moreover, it is unknown whether microbiota-derived metabolites can regulate fatty acid desaturation at the transcriptional level, despite strong evidence for key roles of microbiota in host fat metabolism, including fat storage and insulin sensitivity 3,4,5,26,27,28,29

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