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1 Introduction Numerous scientific studies have confirmed the role of diet in maintaining the proper functioning of the human body and in the prevention and treatment of various diseases, including obesity, diabetes, and cardiovascular disease ( 2 History of the ketogenic diet The earliest reports on the use of a low-carbohydrate diet to reduce the severity of symptoms, especially epileptic seizures, date back to antiquity ( In 1911, French doctors Guelpe and Marie published the first scientific report on the benefits of intermittent fasting in epilepsy ( In 1925, Dr

the label also warns that rash, hives, or swelling of the face, mouth, lips, or tongue can signal a hypersensitivity reaction requiring emergency care, though no generalized allergic reactions were documented in the original trials Because current supply comes only from compounded preparations rather than an FDA-verified finished product, potency, purity, and sterility can vary by pharmacy, and unregulated online sources carry added contamination or mislabeling risk

This reaction depletes the NADPH pool in cells in which the AKR1B1 encoded enzyme is active

10.1126/science.1257132 166

& Strittmatter, P
Excessively low levels can cause a condition known as Laron Syndrome (dwarfism), which is usually diagnosed in childhood
