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biotinylated GSH (biotinylated GSH ethyl ester (BioGEE)) [71], biotinylated GSSG (BioGSSG) [72, 73], anti-GSH antibodies [74] or radiolabelling of the glutathione pool using 35 S-cysteine [75]

This makes it a preferred, safer option for those seeking to optimize wellness and age gracefully from the inside out

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J.BallardC.Ray ChaudhuriK.et al (2021)

Indeed, the human OPRD1 gene has been linked by polymorphisms to individual variations in pain perception and susceptibility to addiction and even psychiatric disorders, demonstrating that the role of this receptor extends far beyond nociception [55,56]

For example, transcription of the T-type calcium channel Ca v 3.2 was shown to be upregulated after pilocarpine-induced status epilepticus [50], which can change the mode of neuronal firing from regular to intrinsic burst firing after acute seizures [51,52], strengthening the propensity of neuronal excitation