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Conversely, excessive levels of oxidants in skeletal muscle, often linked to prolonged exercise, can impair proteins critical to excitationcontraction coupling, thereby inducing muscle fatigue and diminishing the physiological advantages of ROS production during moderate-intensity exercise (58)

Symptoms of vitamin B12 deficiency: extreme tiredness a lack of energy pins and needles a sore and red tongue mouth ulcers muscle weakness problems with your vision psychological problems, which can range from mild depression or anxiety to confusion and dementia problems with memory, understanding and judgement Causes of a vitamin B12 deficiency: pernicious anaemia a lack of these vitamins in your diet medicine certain medicines, including anticonvulsants and proton pump inhibitors (PPIs), can affect how much of these vitamins your body absorbs

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