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To explore the underlying mechanisms of elevated histone lactylation in GSCs, we measured levels of key metabolites in GSCs and DGCs, including products of glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle, by liquid chromatographymass spectrometry (LC-MS), which revealed upregulation of glycolytic metabolites, including lactate, in GSCs (Figure 2, A and B)

The pool of 2HG reflects epigenetic and redox remodeling in IDH-mutant tumors, whereas elevated glycine is associated with increased nucleotide demand and proliferative activity

Inclusion and exclusion criteria Published articles were included in the systematic review and meta-analysis if they met the following criteria: (1) be a randomized controlled trial (RCT)

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