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Accordingly, selective targeting of GSH-dependent nodes (such as cysteine transport, mitochondrial GSH import, compartmentalized GSH degradation, or NADPH-dependent regeneration) may offer greater specificity and efficacy than indiscriminate redox perturbation

Thus, activated p53 promotes ferroptosis in PMB-induced AKI by downregulating SLC7A11 expression and upregulating TfR1 expression

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Chronic morphine treatment significantly alters the gut microbial composition, decreases the Bacteroidetes / Firmicutes ratio, and induces amplification of gram-positive pathogenic bacteria (200)

Furthermore, future research should prioritize large-scale, long-term randomized controlled trials to definitively establish optimal dosing regimens, confirm sustained efficacy across diverse PCOS phenotypesespecially considering inherent heterogeneity and ethnic variations, and rigorously evaluate hard clinical endpoints such as live birth rates, prevention of T2D/cardiovascular events, and endometrial cancer risk reduction