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Environmental factors, such as pH, temperature, and interactions with other ingredients in the formulation, can also impact their stability and functionality [12]

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Berryman DE, Christiansen JS, Johannsson G, Thorner MO, Kopchick JJ

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Using the biweight midcorrelation, a similarity matrix was computed from which a signed network was constructed using a soft-thresholding power of 14 (MBH, DVC) or 16 (LPBN), maximising the scale-free topology R2 fit while keeping mean connectivity to a value 100

Their ligand RMSDs were marginally higher than those of istradefylline, with the MAO-B15 ligand fluctuating at approximately 2.0 and MAO-B20 showing more variation between 1.5 and 2.5
