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Ferroptosis was first discovered in tumor cells when studying RAS mutations

For the analysis, we selected genes that encode key MeOH-metabolizing enzymes ( ADH1, ALDH2, CAT, CYP2E1 , and ADH5 ) and NRF2, which is encoded by the NFE2L2 gene and is a well-known sensor of oxidative stress (Prasad, 2016)

doi: 10.4103/1673-5374.379018

This research was funded by Suzhou Medical Innovation and Applied Research Program, grant number SKY2023103, Suzhou Science and Education Medical Enhancement General Program, grant number MSXM2024067, and Research capacity enhancement project, grant number WWKY202401