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Overall, the overload of oxidized substrates together with the oxidative damage to proteasome lead to the accumulation of abnormal proteins and to selective degeneration of neurons, which characterize the AD condition (FIGURE 10)

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Gary Lopaschuk John Ussher Clifford DL Folmes William C Stanley There is a constant high demand for energy to sustain the continuous contractile activity of the heart, which is met primarily by the beta-oxidation of long-chain fatty acids

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[DOI] [Google Scholar] 94.Hooshmand S., Balakrishnan A., Clark R.M., Owen K.Q., Koo S.I., Arjmandi B.H

doi: 10.1186/1743-7075-7-30