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Interestingly, as -arrestins function as physical and biochemical scaffolds that anchor and recruit endocytic machinery as well as components of the MAPK pathway to endosomes, it is possible that -arrestins may limit ERK translocation to the nucleus, thus promoting cytoplasmic ERK signaling (Bond et al., 2019)

Anti-androgenic Hyperandrogenism is considered the primary endocrine hallmark of PCOS and contributes to both reproductive and metabolic dysfunction [252]

Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys