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He lived in Vancouver, so I'm a Vancouver guy

16(3): BR81-88 ID: 878454 Published: 2010-02-26 Eur J Pharmacol

Structurally, semaglutide is a modified peptide analog of human GLP-1, designed to resist enzymatic degradation and prolong its biological half-life, allowing for once-weekly subcutaneous injection

For patients with refractory disease who've exhausted approved therapies, peptides represent a rational investigational option

As mutated, it causes an early onset autosomal recessive PD

Endocrinol (2012) 153(8):372434
