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Mechanistically, V-9302 sustained glutamine uptake by CD8 + T cells, by promoting the compensatory upregulation of the glutamine transporter ATB 0,+ / Slc6a14 , in CD8 + T cells, to support de novo glutathione synthesis and improve redox balance in T cells

Elevated production of ROS in C9orf72-associated ALS is also associated with abnormalities in mitochondrial function and neuroinflammation (Briehl et al., 2014

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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Ggotek A, Atalay S, Domingues P, Skrzydlewska E

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