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It exists in two optical isomers (S- and R-enantiomers), though only the naturally occurring R-ALA form binds covalently to lysine residues via amide linkages, acting as a cofactor in vital biological processes [8]

In contrast, a small fraction of lymphoma and leukemia cell lines successfully grow in these gels [28, 30], suggesting the presence of TIC or TIC-like cells even in established lymphoma/leukemia cell lines cultured in vitro

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It also helps you make informed decisions about whether to continue escalating, hold at your current dose, or step back down