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doi: 10.1016/j.chemosphere.2022.136757 46 MakryniotisK.NikolaivitsE.GkountelaC.VouyioukaS.TopakasE
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In addition, a meta-analysis of studies of cancer patients treated with cisplatin found that ACYP2 rs1872328, which plays a role in calcium homeostasis, increased the risk of ototoxicity 4.6-fold (95% CI: 3.07.0), and LRP2 rs4668123 increased the risk of ototoxicity 3.5-fold (95% CI: 1.58.5) (144)
A study on the effects of long-term treatment with CoQ 10 (200 mg/day) plus selenium (200 g as selenized yeast) in a homogeneous Swedish healthy elderly population ( n = 219) revealed a significant reduction in cardiovascular mortality not only during the 4-year treatment period, but also 10 years later, compared to those taking either a placebo ( n = 222) or were without treatment ( n = 227) (Alehagen et al., 2015, 2016)
The activity reverts to the original level within 23 days if the agent is withdrawn