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Dihexa significantly decreased levels of pro-inflammatory cytokines including interleukin-1 (IL-1) and tumor necrosis factor- (TNF-), both implicated in synaptic dysfunction and neuronal death in Alzheimer's disease

This can explain the reversed freezing rat behavior as consequent to the L-NAMEinduced retinal ischemia, which was recovered by BPC 157 administration

The BDD (C) in this layer was calculated according to such a formula: C = A B

doi: 10.7554/eLife.56621 63 MatsushimaGKMorellP
