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Lineagespecific differentiation of tissue cells from stem cells is essential for regenerative medicine, especially for cardiovascular system diseases, as the lack of cardiovascular cell regeneration after injury can lead to heart failure, seriously threatening people's health

Even though many questions about managing immune-related side effects remain unanswered, experts agree on the importance of diagnosing immune-related side effects before they progress to more serious complications

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Data availability The authors declare that all data generated or analyzed during this study are available in this published article and its supplementary information files or from the corresponding author upon request