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[DOI] [PMC free article] [PubMed] Rupture, reconstruction, and rehabilitation: A multi-disciplinary review of mechanisms for central nervous system adaptations following anterior cruciate ligament injury

In addition, pro-inflammatory cytokines can act to steal tryptophan away from serotonin and melatonin pathways (via up-regulation of the enzymes IDO and TDO), increasing the activity of the NMDA agonist quinolinic acid, and further antagonising stimulation of NMDA pathways, which subsequently exacerbates mood and sleep issues

Chitosan, a natural polymer, exhibits favorable properties such as biocompatibility, non-toxicity, and biodegradability, making it a widely employed material for drug delivery [95]

Nanotechnology-based platforms and bioengineered carriers offer promising routes to concentrate zinc or zinc-modulating agents within specific organelles while minimizing off-target redistribution and systemic toxicity

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