glutathione activate toxin Apoptosis and glutathione: beyond an antioxidant Toxicity of Glutathione-Binding Metals: A
Description
The role of glutathione in heavy metal responses could be multiple, as many of these elements are considered to directly or indirectly result in enhanced cellular oxidation

[DOI] [PubMed] [Google Scholar] Hall JL

The mutant huntingtin protein can disrupt mitochondrial function and increase ROS production

An important early example investigated the effect of both knockout and transgenic uricase in mice receiving intracerebral 6-hydroxydopamine administration, which leads to dopaminergic neurodegeneration 33

Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2

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